Tead4基因
http://www.shidacloud.com/?p=124625 Web传统的多克隆和单克隆抗体是正常 b 细胞发育和基因重组的产物。它们是通过用抗原免疫动物以引发免疫应答而产生的。多克隆抗体由许多不同的 b 细胞克隆分泌并识别多个抗原表位,而单克隆抗体则来自单个 b 细胞克隆,并且仅对单个表位具有特异性。
Tead4基因
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Webtead4基因编码序列nm_003213.4,tead4蛋白编码序列np_003204.2,tead4基因又名eftr-2; hrtef-1b; rtef1; tcf13l1; tef-3;tef3; tefr-1,tead4基因,tead4蛋白,tead4抗体,tead4表达质 … WebOct 6, 2024 · Abstract. TEA domain transcription factor 4 (TEAD4) is an important member of the TEAD family. As a downstream effector of the Hippo pathway, TEAD4 has essential roles in cell proliferation, cell survival, tissue regeneration, and stem cell maintenance. TEAD4 contains a TEA DNA binding domain that binds the promoters of target genes …
WebApr 5, 2024 · 在此基础上,本项工作主要通过结构生物学、生物化学等技术方法深入解析了Hippo通路下游关键转录因子TEAD4特异性识别结合DNA的机制,发现TEAD4的alpha3 … Web敲减小鼠tead4基因影响肌细胞的融合,导致形成较短的肌管[2]。本研究通过敲减牛tead4基因,探讨了该基因在牛肌肉卫星细胞分化和转分化过程中的作用。本研究根据牛tead4的cDNA序列设计合成短发夹shRNA,构建成tead4敲减慢病毒载体,生产含有干扰片段的病毒,感染牛
WebJun 14, 2024 · Tead4 is one of the earliest transcription factors expressed during mouse embryo preimplantation development and is required for the expression of TE-associated genes. Functional knock-out studies in mouse, inactivating Tead4 by site-specific recombination, have shown that Tead4-targeted embryos have compromised … WebFeb 8, 2024 · Introduction. The TEAD(1–4) transcription factors [1, 2] bind to a consensus MCAT (5’-CATTCCA/T-3’) element, originally identified as the SV40 enhancer GT-II motif [] [4–6], through the evolutionarily conserved TEA/ATTS DNA binding domain [7, 8].Mammalian TEADs are widely expressed with prominent Tead1 and Tead4 …
WebJan 28, 2014 · 当Hippo信号通路激活时,上游激酶磷酸化YAP,被磷酸化的YAP能够与细胞骨架蛋白14-3-3蛋白相互作用,停留在胞质内,不能进入细胞核激活基因转录。Hpo信号通路异常调控则可导致YAP稳定化并进入细胞核,与核内的转录因子相互结合,启动下游靶基因的 …
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