Salarin c synthesis
WebDOI: 10.1016/J.TETLET.2008.05.038 Corpus ID: 96996339; Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide @article{Bishara2008SalarinCA, title={Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide}, author={Ashgan Bishara and Amira Rudi and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman}, … WebAug 17, 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (41,975,589 articles, preprints and more) (41,975,589 articles, preprints and more)
Salarin c synthesis
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WebNov 11, 2013 · Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl …
WebSep 21, 2024 · The synthesis was inspired according to Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. 60. In 2024, a study toward the total synthesis of salarin C was reported. This strategy based on the synthesis of dideoxysalarin C as a potential intermediate for the total synthesis of the marine macrolide salarin C. WebJul 7, 2008 · A novel nitrogenous macrolide, designated salarin C (3), was isolated from the Madagascan sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra.Salarin C is closely related to salarin A and is considered to be the precursor of salarins A and B (1,2).Air oxidation was found to …
WebNov 26, 2024 · A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. … WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described.The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and vinyl iodide 8 and Shiina macrolactonization as key transformations. All macrocyclic intermediates were …
WebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene moieties. In the key step, ring-closing metathesis exclusively afforded the (E)-product. NOESY-based conformational analysis of the macrolactone showed that the oxazole ring …
WebApr 20, 2024 · The synthesis was inspired by Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. Clean conversion to the triacylamine partial structure of salarin A occurred on treatment with photochemically generated singlet oxygen. Thus, a Wasserman-type oxidative rearrangement is chemically possible in this case. shophq careersWebSep 21, 2024 · The synthesis was inspired according to Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. 60. In 2024, a study toward the total … shophq channel on comcastWebOct 24, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … shophq casio watchesWebSynthesis and Stability Studies of a Simplified, Thiazole-Containing Macrocycle of the Anticancer Agent Salarin C . Continue Bridging the gap between natural product synthesis and drug discovery. Continue Pyrrole-2-Aminoimidazole Marine Alkaloids. Continue Total Synthesis of (-)-Salinosporamide A. shophq channelWebNov 1, 2013 · Derivatives of salarin A, salarin C and tulearin A were prepared and bio-evaluated as inhibitors of K562 leukemia cells and interesting preliminary SAR (structure activity relationship) information was obtained from the products. Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were … shophq celine dion handbagsWebNov 12, 2013 · In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s … shophq christopher banksWebDec 7, 2024 · A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and … shophq cast