Web8 feb. 2024 · Background Protein posttranslational modification is an indispensable regulatory element that can fine-tune protein functions and regulate diverse cellular processes. Lysine 2-hydroxyisobutyrylation (Khib) is a protein posttranslational modification that was recently identified and is thought to play a role in a wide variety of … Web5 jun. 2024 · Background Lysine 2-hydroxyisobutyrylation (Khib), a newly identified post-translational modification, is known to regulate transcriptional activity in animals. However, extensive studies of the lysine 2-hydroxyisobutyrylome in plants and animals have yet to be performed. Results In this study, using LC-MS/MS qualitative proteomics strategies, we …
Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI …
WebLysine 2-hydroxyisobutyrylation (Khib) is an evolutionarily conserved and widespread histone mark like lysine acetylation (Kac). Here we report that p300 functions as a lysine 2-hyroxyisobutyryltransferase to regulate glycolysis in response to nutritional cues. Web教研室成立于1958年。. 主要承担《药理学》、《中药药理学》、《高等药理学》、《系统药理学》、《新药研制原理与技术》、《专业英语》等本科和研究生课程的教学任务。. 目前本教研室共有教师15名，其中具有博士学位的占86.7%，具有高级职称的占73.3 % ... marie therese robert
Comprehensive identification of lysine 2-hydroxyisobutyrylated …
Web1 jun. 2024 · As a new type of histone mark, lysine 2-Hydroxyisobutyrylation (Khib) is known to affect the association between histone and DNA. The accurate identification of Khib sites is significant for ... Web1 mrt. 2024 · Lysine 2-hydroxyisobutyrylation (K hib) is a novel protein posttranslational modification conserved in eukaryotes and prokaryotes.However, the biological significance of K hib remains largely unknown. Here, through screening the proteome-wide K hib modification sites in bacteria using a bioinformatic method, we identified a potential K hib … WebWe report the identification of a new type of histone mark, lysine 2-hydroxyisobutyrylation (Khib), and identify the mark at 63 human and mouse histone Khib sites, including 27 … marie therese robin