Horses. Cisplatin is used intralesionally to treat equine skin tumors such as sarcoids, spindle-cell tumors, squamous cell carcinoma, and melanoma. When used as an intra-lesional injection, cisplatin is either mixed with sterile sesame oil or delivered in a biodegradable, slow release bead. See more Cisplatin is a platinum-containing chemotherapy drug. Although the mechanism of action is not understood completely, cisplatin behaves similarly to a bi-functional alkylating agent by producing cross links in DNA. … See more WebNov 15, 2006 · OBJECTIVE To determine outcome for equids with cutaneous neoplasms treated with cisplatin-containing biodegradable beads, alone or in conjunction with debulking. DESIGN Retrospective case series. ANIMALS 56 horses, 1 zebra, 1 donkey, and 1 mule. PROCEDURES Medical records were reviewed.
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WebMatrix III is a calcium-based matrix for depot delivery of pharmaceuticals. Matrix III Cisplatin Beads have received MUMS (Minor Use Minor Species) designation from the FDA – Center for Veterinary Medicine (CVM), and is currently undergoing clinical trial in the treatment of equine sarcoids. WebCisplatin (cis-diammine dichloroplatinum) is a heavy metal compound that inhibits DNA synthesis by directly binding to DNA and is commonly used in equine medicine. Two approaches are available for controlled-release … small pool contractors
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WebDec 29, 2000 · Cisplatin is a heavy metal compound that stops cell division and causes cell death. It has been used by intratumoral (into the tumor) injection in the treatment of sarcoids with an 87% success... WebCisplatin (a chemotherapeutic agent designed to kill tumors) is often effective against tumor cells if it can be kept in the affected region. In horses (and non-food animals), the bead … WebThe beads themselves are expensive, though implantation is a rather simple procedure, and have a very high success rate. Some tumors may require an additional treatment. Cisplatin beads may be implanted directly under small tumors or larger tumors excised followed by bead implantation. small pool covers