WebCefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) … WebApr 1, 2024 · Class-specific neurologic effects. Certain antibiotics have class-specific effects: Tetracyclines: cranial nerve toxicity, neuromuscular blockade, and intracranial hypertension. 2 Sulfamethoxazole-trimethoprim: tremors and psychosis, with visual and auditory hallucinations. 6 Macrolides: dysequilibrium and potentially irreversible hearing …
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WebAn additional risk factor for cefepime neurotoxicity is premorbid CNS disease.7,21-23 The mechanism of toxicity is thought to be due to concentration-dependent GABA antago … WebSep 19, 2024 · Review the toxicity of third-generation cephalosporins. ... Lyme disease with CNS involvement and with or without parenchymal involvement. ... The fourth-generation cephalosporins (e.g., cefepime), while retaining their activity against gram-negative like third-generation, also have improved gram-positive activity. ... terry lowery lumberton nc
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WebOct 1, 2024 · 1. Introduction. There exists a considerable body of literature on the increased risk of developing epileptic seizures as an adverse effect of antibiotic therapy. β-lactams and fluoroquinolones are most frequently associated with central nervous system toxicity and neurological side effects [1].Although infrequent, other classes of antibiotics have also … Webrequested cefepime therapeutic drug monitoring (TDM) for either suspicion of toxicity or renal insufficiency [7]. Six patients had clinical neurotoxicity attributed to cefepime; investigators concluded that a trough level 22 mg/L led to a neurotoxicity probability of 50%. The study was limited by confounding by indi- WebJun 23, 2024 · Capitano B, Nicolau DP, Potoski BA, et al. Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections. Pharmacotherapy 2004; 24:803. Wrenn RH, Cluck D, Kennedy L, et al. Extended infusion compared to standard infusion cefepime as empiric treatment of febrile neutropenia. terry lowitz dds